Sespia ("of Sespe Creek") is an extinct genus of oreodont endemic to North America.

They lived during the Late Oligocene 26.3—24.8 mya, existing for approximately 1.5 million years.

[citation needed] The genus was closely related to the larger Leptauchenia.

Fossils of the best known species, the cat-sized S. californica, have been found California and are known from literally thousands of specimens.

The largest species, the goat-sized S. ultima, is known from late Oligocene deposits in Nebraska.