In the Middle Age, the locality was called Campo dei Sette Fratelli ("Field of the Seven Brothers") or Forno dei Septe Fratri ("Oven of the Seven Brothers"): both names were related to the legend of Saint Symphorosa and her seven children, (Crescens, Eugenius, Julian, Justin, Nemesius, Primitivus and Stracteus), martyred in the near Tibur (present Tivoli, Lazio, Italy) toward the end of the reign of the Roman Emperor Hadrian.

The modern settlement developed as a rural village at the beginning of the twentieth century, on some lands owned by the Duke Leopoldo Torlonia.

Settecamini is located in the eastern part of the city, near the Grande Raccordo Anulare, and borders the municipality of Guidonia Montecelio.

To the north, Settecamini borders with Zona Tor San Giovanni (Z. V), whose boundary is marked by the stretch of Via Nomentana between the Grande Raccordo Anulare and Via Palombarense.

Other streets and squares are chiefly dedicated to medieval authors, municipalities of Abruzzo and Molise (in the frazione of Case Rosse) and to engineers and scientists (in the area of Tecnopolo).