[1] After she passed the exam, the Ministry of Education refused to validate the signatures of the instructors who had conducted it, thus denying Kallisperi's entrance to the university.

[3][4] She appealed, and the mayor of Athens validated the signatures and granted her a public high school diploma, but her entrance to the university was still denied.

During the same time frame, Kallisperi privately taught girls in her home in ethics, history, Greek and French literature, and psychology.

In 1897, The Family Journal published her paper, Περί μεταρρυθμίσεως του γυναικείου Εκπαιδευτικού συστήματος (For reforming of the women's educational system).

[1] That same year, Kallisperi joined with other feminists to found the Union for Women's Education and began publishing in such journals as Thalia and Euridice.

Part of her trip to the United States was to be spent evaluating public schools in Boston, Philadelphia and New York for ideas which might be brought to bear in Greece.

[7] She remained in the United States for five years, visiting Greek communities in Ohio, Colorado and Utah to study agricultural trade schools, before returning to Washington, D. C. to attend the 1908 Mother's Congress.

In addition to her calls for improvement in education, she also wrote analyses of ancient Greek literature, translated foreign plays, as well as writing poetry and publishing her memoirs.

[1] Between 1907 and 1919, Kallisperi and her brother George bought 4 adjacent lots in Athens and erected several buildings upon them, beginning with a neoclassical house begun in 1911.