The Line 2 of the Metro of Seville will span the city from east to west, connecting the neighbourhoods of La Cartuja and Torreblanca.

The line will begin in the neighbourhood of Torreblanca and will proceed to pass through Sevilla Este and el Palacio de Congresos, Montesierra, Tesalónica (with a line 4 connection expected), Kansas City, the central station of Santa Justa, José Laguillo (a planned line 3 station), la Plaza del Duque, the Plaza de Armas bus station, before finally crossing the river to Torre Triana (a planned line 4 station).

This line is of vital importance in terms of the trajectory that it spans, especially since it passes beneath the historic centre of the city and connects the international bus station of Plaza de Armas with the central railroad station of Santa Justa.

Consequently, it has been though necessary to advance the modernization of the existing metro and railway installations, thereby providing a direct connection between the international bus station and the high velocity train (AVE) station of Santa Justa.

These stations would be: Camas, Airesur (commercial center), Nueva Sevilla, Bormujos-Gines and Hospital de San Juan de Dios (Bormujos).