She acted in various theatre productions (for plays like Asylum, at Thespo 11 and Utter Cupidity) and later on several short films with Whistling Woods International till March 2011.
From hosting TV shows in the genre of lifestyle, Bollywood & cooking to international on-ground events, Dr. Khera is known to bring a gust of energy and charisma to the screen with her wit and charm.
During the lockdown in 2020, Shamoly hosted her talk show called ‘Stay Home Stay Inspired.’ Some of the popular names on this show were Manav Kaul, Amit Gaur, Rajat Barmecha, Nitinn Miranni, Pankaj Mishra, Dr. Anjali Mukerjee, Malini Agarwal amongst others.
In 2019, Dr. Khera got an opportunity to represent India in Taiwan, via the show embracing Taiwan, produced by Zee International, where she got the opportunity to interview and interact with leading Taiwanese ministers & entrepreneurs like Joseph Wu, Minister of Foreign Affairs, Tseng Hou-jen, Diplomat and Theodore Huang amongst others.
Dr. Shamoly Khera's debut book Bedazzle –The Art & Science of Confidence was published by Bloomsbury India in December 2020 and has been trending in the bestseller self-help genre.