[2] Spitse started her career at VV Sneek before joining SC Heerenveen when the Eredivisie Vrouwen, the Dutch women's professional league, was established in 2007.

[12] On 19 December 2016, during the 2015–16 Eredivisie winter break, she moved back to the Netherlands, agreeing to a contract with FC Twente for the second half of the season.

[14] During the 2017–18 Eredivisie winter break, on 27 December 2017, she signed a two-year contract with Vålerenga Fotball, returning to the Norwegian Toppserien.

[17] Spitse made her debut for the Netherlands national team under coach Vera Pauw on 31 August 2006, in a 4–0 World Cup qualifying defeat to England.

[21] In June 2013, national team coach Roger Reijners selected Spitse for the UEFA Women's Euro 2013 in Sweden.

[23] Spitse helped the Netherlands qualify for the 2015 FIFA Women's World Cup and was selected for the final squad.

[29][30] Spitse suffered a knee injury in July 2021, forcing her to miss the rescheduled 2020 Tokyo Summer Olympics.