In 1981, he co-authored a collection of short stories titled Yume de Aimashou ("Let's meet in a dream") with writer Haruki Murakami.

Under the theme of "creating good mood", the website has been updated every day for the past 15 years, with Itoi's essays on lifestyle, interviews and articles, and merchandise sales.

He talks about his pet dogs and his interviews with artists, craftsmen, businessmen, etc., which tend to center on philosophical issues.

Itoi has co-written several books modeled on these interviews, in which he has a series of long conversations with, for example, an expert on neurology Yūji Ikegaya, about how to live as a human being in the world.

Itoi has voiced Satsuki's father, Tatsuo Kusakabe, in the original Japanese version of the 1988 Studio Ghibli film My Neighbor Totoro.

He made his live-action acting debut in 2010, when he played the role of a professor in the film adaptation of Haruki Murakami's Norwegian Wood.

[4] Itoi claims that the final battle of EarthBound with Giygas was inspired from his accidental childhood viewing of the Shintoho film titled The Military Policeman and the Dismembered Beauty.

Dokonoko is most famous for a particular Japanese Labrador Retriever named Corky, who made front line news because of the abnormal length of her tongue.