[4] In performances around 1958, the Isley Brothers would typically end their shows with a cover version of Jackie Wilson's hit "Lonely Teardrops".

At one performance at the Uptown Theater in Philadelphia, lead singer Ronald Isley could see the audience standing and yelling their approval, so he extended the song by improvising a call-and-response around the words "You know you make me wanna..." "Shout!".

Ronald Isley later said that church groups wrote to radio stations asking them to stop playing the record, because of its use of a traditional black gospel sound.

They also reworked the chorus portion of the song into an even bigger hit, "Peppermint Twist", while the Isley Brothers' version re-charted that same year at number 94.

[11] The National Football League (NFL)'s Buffalo Bills commissioned a version of "Shout" in 1987 with modified lyrics sung by jingle writer Scott Kemper.

[14] The song was prominently featured in Elvira: Mistress of the Dark, but they could not afford to license the original recording, so it was covered by Larry Wright.

Louchie Lou & Michie One recorded a ragga/rap version of the song, titled "Shout (It Out)", which reached number 7 on the UK chart in 1993.