Shridhar Ramachandra Gadre (born 20 May 1950) is an Indian scientist working in computational quantum and theoretical chemistry.

During his post-doctoral work, Gadre carried out research in density functional theory and on rigorous inequalities in quantum chemistry.

Since joining the University of Pune, Gadre's work has focused on the study of molecular scalar fields and their topographical characteristics.

Gadre has been at the forefront of investigating chemical reactivity and weak interactions through the use of molecular electrostatics potentials and momentum densities.

This approach is now extended to perform geometry optimisation as well as Hessian (vibrational frequency) calculation of large molecules in an efficient manner even on a common personal computer.