Holmes later worked as a civil engineer, and was employed on the Chenango and Black River Canals and the New York and Erie Railroad.

He was a Loan commissioner for Madison County from 1848 to 1851, responsible for obtaining approval for and overseeing expenditure of money borrowed for public works improvements.

In addition to aiding in recruiting efforts, in 1862 he served as a Loan Commissioner for funds borrowed to train and equip soldiers from Madison County.

In 1872 Holmes traveled in the western United States while attempting to restore his failing health, and was impressed with the activity and possibilities of Bay City, Michigan.

Holmes Planing Mill, Sash, Door & Blind Factory, Grand Rapids, Michigan.