In 1268, Baibars besieged the city of Antioch, which was "badly defended by its patriarch and abandoned by most of its inhabitants,"[2] capturing it on 18 May (the citadel fell two days later) after a relatively feeble defense.

Before Baibars' forces laid siege on Antioch, the Constable Simon Mansel, along with a group of knights, led an unsuccessful attack against the Muslim army in order that the city should not be encircled.

Mansel was captured during the Antiochene cavalry attack, and Baibars ordered him to command his lieutenants in Antioch to surrender immediately.

In a single day the city of Antioch lost all its inhabitants and a conflagration lighted by order of Bibars completed the work of the barbarians.

Every man in the city was put to the sword – they numbered more than a hundred thousand.For three days Antioch was sacked, in which 17,000 persons were killed and 100,000 taken prisoners.

By the time of his death in 1277, Baibars had confined the Crusaders to a few strongholds along the coast and they were forced out of the Middle East by the beginning of the fourteenth century.