Simolândia is situated in the northeast of Goiás, at kilometer 250 of the important BR-020 (Belém-Brasília highway).

Highway connections are made by BR-153 / Anápolis / BR-060 / Alexânia / Sobradinho / Planaltina / Formosa / BR-020 / BR-030 / BR-020 / Vila Boa / Alvorada do Norte.

[2] The municipality lies mainly on the slopes of the Serra da Chapadinha and the topography is broken by several rivers: the Corrente, Salobro and Buriti, which are popular with tourists.

The economy is based on subsistence agriculture, cattle raising (19,100 head in 2006), services, public administration, and small transformation industries.

Agricultural data 2006 Simolândia was ranked 233 out of 242 municipalities in the state of Goiás on the United Nations Human Development Index with a score of 0.657.