Simon II of Clermont-Nesle (c. 1210–1285/86) was Seigneur (Lord) of Ailly, Maulette and Nesle (in Picardy) Simon was the eldest son Raoul I of Clermont-Nesle, Seigneur of Ailly, Maulette, and Gertrude of Nesle.

[2] Jointly with Matthew of Vendôme, Simon was the regent of the kingdom in 1270–71 when Louis and his son Philip were away on the Eighth Crusade, using the title "lieutenant".

Simon was also a tutor of the children of the king, appointed by Philip III.

Simon is accounted of the foundation of Hôtel de Nesle, to accommodate nobility in Paris, instead of their first Hôtel de Nesle, that was ceded to King Louis IX, and the construction was enabled through the prominent positions of his sons Raoul and Guy, and their wealth.

The hotel was connected to Tour de Nesle, and eventually sold to King Philip IV of France in 1314.