[4] The name of the novel is a parody of the term "homosexual agenda", a pejorative phrase that is commonly used by opponents of gay rights in the United States.

This is also a reference to a conversation between Simon and his email pen pal, in which they discuss how they believe everyone should have to come out, not just gay people, jokingly referencing the aforementioned phrase and how their own version would be "the Homo Sapiens Agenda", since it applies to everyone regardless of sexuality.

The book was adapted into a film titled Love, Simon, which was released by 20th Century Fox in the United States on March 16, 2018, and was met with critical and commercial success.

Simon Spier is a closeted, gay, 16-year-old student in his junior year of high school with a fondness for musical theater who lives in a suburb of Atlanta, Georgia.

[8] Development of the film by production studio Fox 2000 was first reported in October 2015, with Elizabeth Berger and Isaac Aptaker signed to write the screenplay.