Sisseton is a city in Roberts County, South Dakota, United States.

The city is named for the Sisseton (or Sissetowan) division of the Native American Sioux.

[7] It also serves as an important part of the Lake Traverse Indian Reservation.

[8] According to the United States Census Bureau, the city has a total area of 1.59 square miles (4.12 km2), all land.

[9] Sisseton has a relatively dry, four-season, humid continental climate (Köppen: Dfb/Dfa), with long, dry, cold winters, hot summers, and brief spring and autumnal transitions; like much of the southern half of the state, it lies in USDA Plant Hardiness zone 5.

34.9% of all households were made up of individuals, and 16.3% had someone living alone who was 65 years of age or older.

34.6% of all households were made up of individuals, and 16.2% had someone living alone who was 65 years of age or older.

Intercity bus service to the city is provided by Jefferson Lines.