The film was directed by Wenn V. Deramas and stars an ensemble cast including Ai-Ai delas Alas, Vice Ganda and Kris Aquino, alongside Kathryn Bernardo, Daniel Padilla, Tirso Cruz III, Epi Quizon, DJ Durano, Gloria Diaz and Xyriel Manabat in their supporting roles.

Detty struggles financially after her tailor shop goes bankrupt and fights for custody of her children, Kathy and Cindy, from her ex-husband.

At the Run Away Fashion Show, Bernice confronts his rival, Roselle Hermosa, who owns the competing brand La Yondelle and is vying for a European partnership deal.

La Yondelle's collection is revealed to be stolen from Ponytale, prompting Detty to quickly revise the fashion line.

Roselle hires Brazilian Filipino model Marlon as her brand's endorser and asks Bernice's design partner James, who is a mole in Ponytale, to convince Detty to join La Yondelle.

Bernice devises an elaborate plan to scare Roselle with two employees in a costume of ghostly flower girl (a parody of Sukob) and Lotus Feet (a parody of Feng Shui), which causes her to fall down a flight of stairs and fracture her foot, and the latter vows revenge against Ponytale, which is facing dwindling sales.

Bernice's close friend Jessie advises him to get back Detty and forget about his revenge scheme if he wants Ponytale to emerge successful.

[4] According to Kris Aquino's official Twitter account, she reported that Sisterakas grossed P207.3 million after its first seven days in theaters.

In comparison, The Unkabogable Praybeyt Benjamin, the highest-grossing Philippine film at the time, grossed P200 million after eight days in theaters nationwide.

[citation needed] It officially surpassed the record of then-second all-time highest-grossing Philippine of all time, No Other Woman, which stars Anne Curtis.

Also released by Star Cinema and Viva Films, No Other Woman has a total box-office take of P278.39 million, according to the data gathered from Box Office Mojo.

Sisterakas now places itself on the second spot behind from The Unkabogable Praybeyt Benjamin in the list of the Philippines' all-time box-office films.

Also directed by Wenn V. Deramas and stars Vice Ganda, Praybeyt Benjamin earned P331.61 million after its local theatrical run, according from Box Office Mojo.