The Basin represents a deep and sunken depression along the fault lines and is fully integrated into the composition of the Vardar Tectonic Zone.

Ethnographic regions and areas within the Skopje Basin include Skopska Blatija, Karšijak, Torbešija, Crna Gora, Žeden, and Skopski Derven.

After World War I, migrations to the Skopje Basin from various parts of Macedonia, as well as from territories of the former Yugoslavia, reached their peak, and they continue to this day.

The geographical position, terrain, climate, and soil in the Skopje Basin are highly favourable for agriculture and livestock farming.

The most cultivated vegetables and horticultural crops include tomatoes (the famous variety "Skopski jabučar"), peppers (green peppers), onions, young onions, and leeks (in the village of Dračevo), cabbage (in the villages of Bardovci, Zlokukjani, and Dračevo), lettuce, carrots, potatoes, beans, and peas.

Fruit cultivation is mainly found in the hilly areas at the foot of the surrounding mountains in the southern, eastern, and northern parts of the basin.