It is a microaerophilic secondary endosymbiont of the tsetse fly.
[1] Sodalis glossinidius is the only gammaproteobacterial insect symbiont to be cultured and thus amenable to genetic modification, suggesting that it could be used as part of a control strategy by vectoring antitrypanosome genes.
The organism may increase the susceptibility of tsetse flies to trypanosomes.
[2] Despite gene erosion and pseudogene multiplication in a genome of Sodalis glossinidius,[3] these pseudogenes remain actively transcribed.
[4] S. glossinidius is itself host to a prophage discovered by Clark et al. 2007.