Somatomedin

Somatomedins are a group of proteins produced predominantly by the liver when growth hormones act on target tissue.

Somatomedins inhibit the release of growth hormones by acting directly on anterior pituitary and by stimulating the secretion of somatostatin from the hypothalamus.

Somatomedins are a group of proteins that promote cell growth and division in response to stimulation by growth hormone (GH), also known as somatotropin (STH).

Thus, levels of somatomedins are controlled via negative feedback through the intermediates of somatostatin and growth hormone.

The liver is thought to be the predominant source of circulating somatomedins.