The Songwe's headwaters are where the borders of Malawi, Tanzania, and Zambia meet.

The middle course separates Malawi's Misuku Hills from the Umalila Mountains in Songwe Region Tanzania.

The lower course flows through the Kyela Plain, a fertile lowland lying northwest of Lake Malawi the valley of the East African Rift.

The Kyela Plain is cultivated intensively with rice and other crops.

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