Songwe also borders the Tanzanian regions of Rukwa and Katavi in the west, Tabora in the north, and Mbeya in the east.

[6][7] The Songwe Region is situated in Tanzania's southern highlands, between latitudes 7° and 9° 36' south of the equator, and between longitudes 30° and 33° 41' east of the Greenwich meridian.

[4] The East African Great Rift Valley's northern and western arms extend from north of Lake Nyasa, creating the naturally tropical Songwe Region.

[10] Additionally, the region is well-known for producing a number of cash crops, primarily coffee, pyrethrum, sunflower, sesame, tobacco, and peanut.

Numerous animals are kept by Songwe, including pigs (79,513), chickens (79,513), donkeys (4,739), goats (244,024), sheep (33,599), and 410,390 cattle (1,137,708).

Milling machines (1,328) and carpentry (559), welding (158), garage (130), and oil processing were the top four small-scale enterprises, out of a total of 2,320.

[14] Both the Tanzam Highway and the TAZARA Railway run through Vwawa and Tunduma in the southern part of the Songwe Region.

Historic locations including Nyayo za Watu wa Kale, Galula Catholic Church Mti wa Mapumziko-Wakoloni, Kisima cha Wakoloni, Jiwe la, Michoro ya Kale, Unyayo Kwenye Mwamba, Mwenetontela and Makaburi ya Wakoloni.

[5] The local government areas now comprising Songwe Region reported a combined population of 998,862 in the 2012 census, 46 percent of whom were under 15 years old.

According to the National Bureau of Statistics' (NBS) 2018 population forecasts, there were 610,981 women and 562,686 men living in Songwe Region as of the end of 2017.