Launched on May 12, 2005, the comic was originally drawn in black and white, but became full color on August 19, 2005.
The story, which is completed as of Oct 17, 2016, chronicles the life of Danny Gunn, a school teacher who is also an aspiring sorcerer.
While the comic has a largely supernatural cast, the storyline deals primarily with interpersonal relationships.
The comic presents werewolves, vampires, and demons as essentially "normal" people dealing with their own talents and limitations.
Along with a myriad cast of his friends and acquaintances, including but not limited to: his best friend Brad Wolfe; Brad's wife Ally and their daughter Rebecca; Danny's teacher, a vampire named Pat Warren; and the enigmatic elder vampire Seth, who has his own plans for Danny.
In the series, vampires, demons, and werewolves have recently been discovered to be real, though most residents of this world still believe they are a hoax.
Many works of popular culture like the film Star Wars and the TV show Avatar: The Last Airbender appear in the Sorcery 101 world.
Born the prince of Terra, Danny gives up his royal heritage after forming a blood bond with Seth.
Some time before the story begins, he moved in with his friends, Brad and Ally Wolfe, in order to help babysit their rambunctious and preternaturally strong 5-year-old werewolf daughter Rebecca.
Danny is teaching Con Law at a private all-boys high school wherein Jeff and Connor were in his class.
the only time he has shown any violent behavior was when Ally was injured during the story arc "Wild Things."
Brad sports wolf-like characteristics throughout Sorcery 101 while in human form, such as increased strength and being colorblind.
Despite his dislike of werewolves and because of some trickery by Seth, Pat is protecting Jeff from capture by other vampires.
He is apparently quite famous in the vampiric community, with legends that he may be a storm god, the Antichrist, or—his favorite rumor—that he was kicked out of Hell for fear of taking it over.
Since Brad is at the movies, Ally is at work, and Pat is sleeping, Danny is forced to ask Seth for help.
Ally and Danny go to stake out his house that next full moon but unfortunately Jeff is out drinking with his friend Connor.
Danny, Brad, and Seth then go to rescue Jeff from a vampire named Suryu, who is the one selling him.