Located close to the village center, the station was (when) by the Chemins de fer Orientaux, (now part of OSE).

The station lies on the line, built by the Chemins de fer Orientaux (CO), from Istanbul to Vienna.

The railway reached Lagyna during Ottoman rule, when in 1873, when the line from Istanbul to Edirne and Bulgaria was opened.

In 2009, with the Greek debt crisis unfolding OSE's Management was forced to reduce services across the network.

[9] In February 2015 flooding coursed severe delays across the whole line[10] as points failed and embankments where wash away in and around Soufli.

[16] As of 2020[update], Soufli is only serviced by one daily pair of Regional trains Alexandroupoli–Ormenio [16] The station is served by two buses to Alexandroupoli Port (07:31 & 20:33) and a single bus to Dikaia (16:52).

Between July 2005 and February 2011[17] the Friendship Express (an international InterCity train jointly operated by the Turkish State Railways (TCDD) and TrainOSE linking Istanbul's Sirkeci Terminal, Turkey and Thessaloniki, Greece) passed through Lagyna, but did not call at the station.