South Carolina Highway 130 (SC 130) is a 30.072-mile (48.396 km) state highway in Oconee County, South Carolina, connecting Clemson and eastern Oconee County with access to Lake Keowee, Lake Jocassee, and the Blue Ridge Mountains.

SC 130 travels generally in a south–north direction, beginning at a major intersection with South Carolina Highway 59 in downtown Seneca.

[2] The route continues northward and passes through the small town of Salem before intersecting with the Cherokee Foothills Scenic Highway (SC 11).

Shortly before crossing into North Carolina, there are several overlooks offering attractive vistas of Lake Jocassee and the Upstate region.

Upon crossing the state line, the route offers access to the Whitewater Falls recreation area.