Finally, Highway 11 passes into Cherokee County, crossing Interstate 85 near Gaffney and ending shortly thereafter.

This National Scenic Byway winds its way through Upstate South Carolina and passes through some towns, such as Walhalla, Marietta, Campobello, Chesnee, and Gaffney.

Echoes of the area's Cherokee heritage can still be heard in places and river names like Seneca, Savannah, Keowee, Jocassee, Enoree, Toxaway, Tugaloo, Tokena, and Eastatoee.

In the city of Gaffney, east of I-85, SC 11 is known as "Floyd Baker Boulevard," which is a well-known street name in Upstate South Carolina.

In 1976, it was decommissioned and was mostly downgraded to secondary roads, with the exception of a small portion of SC 130, which had been extended into Salem by this time.