SC 135 begins at an intersection with U.S. Route 178 (US 178, Moorefield Memorial Highway) southeast of Liberty within Pickens County.

It travels to the northeast and crosses Carmel Creek before entering Easley.

It passes a U.S. Post Office and Gettys Middle School before intersecting SC 93 (Main Street).

It immediately crosses over railroad tracks and turns right onto NE Main Street.

SC 135 travels in a fairly northerly direction and crosses over Burdine Creek.