It travels from U.S. Route 76 (US 76) and SC 28 in Clemson northeast to US 123 in Easley.

West of this point, Old Greenville Highway passes through downtown Clemson and the campus of Clemson University and is signed as SC 93 though it is not officially part of the highway.

[2][3] SC 93 heads northeast exiting the city, it then has an interchange with US 123.

After leaving downtown, SC 93 meets US 123 one last time, where its northern terminus lies.

When this was finished, all of former US 123 from Easley to Clemson was renumbered as today's SC 93.