South Carolina Highway 145 (SC 145) is a 26.150-mile (42.084 km) primary state highway in the U.S. state of South Carolina.

The highway has been designated as the Carolina Sandhills Parkway by the SC General Assembly.

SC 145 is a two-lane rural highway that traverses from U.S. Route 1 (US 1) near McBee, through the county seat of Chesterfield, to the North Carolina state line.

In 1948, it was downgraded to secondary status, known today as McLeod Road.

[3] South Carolina Highway 85 (SC 85) was established in 1938 as a renumbering of SC 95, it traveled from US 1, near McBee, through Chesterfield, to the North Carolina state line, north-northeast of Chesterfield.