The highway connects Norris with rural areas of Pickens, via Six Mile.

It travels to the northwest and crosses over Twelve Mile Creek just north of Cateechee.

In Six Mile, the highway intersects SC 133 (South Main Street).

The two highways travel concurrently until Six Mile Cemetery, where SC 133 splits off onto Mt.

A short distance later, it meets its northern terminus, an intersection with SC 183 (Walhalla Highway).