South Carolina Highway 742 (SC 742) is a 3.510-mile (5.649 km) primary state highway in the U.S. state of South Carolina.

It connects Chesterfield with Wadesboro, North Carolina.

SC 742 is a two-lane rural highway that traverses from SC 145, near Chesterfield, to the North Carolina state line.

[2] It was established in 1942 as a renumbering of SC 850 and to match NC 742, little has changed since.

The entire route is in Chesterfield County.