The highway travels through mostly rural areas of Anderson County.

The two highways travel concurrently to the northwest and cross over part of Lake Hartwell on the Calvin Wesley Belcher Bridge.

A short distance later, they split at the Portman Shoals Intersection, with SC 187 traveling to the north.

Just to the west of La France, the highway passes Pendleton High School.

Farther to the northeast, it meets its northern terminus, an intersection with US 76/SC 28, just south of Pendleton.