The highway travels through mostly rural areas of Newberry and Fairfield counties.

SC 213 begins at an intersection with U.S. Route 176 (US 176) southeast of Pomaria within Newberry County, where the roadway continues as Parr Road.

A short distance later, the highway crosses over the Broad River, Hampton Island and some railroad tracks on an unnamed bridge.

The two highways travel concurrently along the southeastern edge of the Monticello Reservoir.

After a short rural section, it meets its eastern terminus, an intersection with US 321/SC 34 just southwest of Winnsboro Mills.