SC 34 begins as a hidden highway in downtown Greenwood, at the intersection of Main Street and Maxwell Avenue.

On city and state official maps, SC 34 is on an east parallel to U.S. Route 25 Business (US 25 Bus.)

along Main Street with some sections being in concurrency; however, no signage identifies this unique relationship, thus the hidden status for 1.6 miles (2.6 km).

Near Newberry, it takes a bypass route along Dixie Drive and Wilson Road, before continuing east to Winnsboro.

Continuing east and parallel to Interstate 20 (I-20), SC 34 joins with US 15 at Bishopville and skirts north of Lee State Park.

Heading in a northeasterly direction now, it goes through Brownsville then east into downtown Dillon, where it ends at the intersection of Main Street and Second Avenue.

An original part of the South Carolina state route system, in 1922 the road ran from Darlington to Ridgeway.

In 1933 the road was extended to Dillon and about 1943 a bridge over the Pee Dee river was opened.

It begins at an intersection with the SC 34 mainline (Dogwood Drive in the northwestern part of the town.

The two highways travel through a residential area and then intersect the SC 34 mainline again.

This ramp heads to the south-southeast and crosses over Indian Creek before merging into US 52/US 401.

At this intersection, US 401 splits off to the southwest, while US 52 and SC 34 Truck continue to the southeast.

They begin a curve to the east-southeast and pass Brockington Elementary School.

At this intersection, US 52 turns right and takes South Main Street tot the south-southeast, while SC 34 Truck continues to the east-southeast.

It crosses over the SCRF rail line again before intersecting South Charleston Road.

It curves to the north-northeast and crosses over Black Creek on the Williamson's Bridge.

Here, the truck route reaches its eastern terminus, an intersection with SC 34.