South Carolina Highway 225 (SC 225) is a 5.900-mile (9.495 km) state highway in the U.S. state of South Carolina that travels southwest of Greenwood.

The easternmost 1⁄2 mile (0.80 km) of the highway is known as West Scotch Cross Road.

SC 225 begins at the U.S. Route 25 (US 25)/US 178 concurrency southeast of Greenwood.

[2] The original SC 225 was established in 1940 as a new primary route, running from Waterloo to Cross Hill.

The route was soon extended west to just east of Ware Shoals.