South Carolina Highway 246 (SC 246) is a 28.700-mile (46.188 km) primary state highway in the U.S. state of South Carolina.

It connects the communities and towns in eastern Greenwood County.

SC 246 is a two-lane rural highway that traverses from Friendship to Hodges; connecting the town of Ninety Six and the communities of Coronaca and Cokesbury.

The highway also provides access to Star Fort Pond, at Ninety Six National Historic Site, via Kinard Road (S-24-27).

By 1942, SC 246 was extended northwest again along US 178 to Tinsley then west to SC 20/SC 185, in Due West; this marked the longest point for the highway.