Known as "the road to the beach" by many residents of the Charlotte metropolitan area due to it being the most direct route to the Grand Strand, it connects the Charlotte metropolitan area to Darlington, Florence, and the aforementioned Grand Strand.

SC 151 starts in Pageland, splitting off from US 601 to bypass the town's business district.

Past McBee, the route takes on a more east-west direction, which it maintains until its southern terminus in Darlington.

In 1983, SC 151 was extended and bypassed east of Pageland, to its current northern terminus.

By the end of 1926, it was extended again to the North Carolina state line, at a point north-northwest of Pageland.

is a 3.190-mile (5.134 km) business route that follows Main Street through downtown Jefferson.

is a 3.030-mile (4.876 km) business route that travels through downtown Pageland via Pearl Street.