South Carolina Highway 358 (SC 358) is a 3.330-mile (5.359 km) state highway in the western part of the U.S. state of South Carolina.

It travels from Lyman through more rural and suburban parts of Spartanburg County.

The highway starts at SC 357 northwest of Lyman.

It heads along the two-lane Holly Springs Road towards central Lyman passing numerous houses, some churches, and a pair of schools.

As it approaches its terminus within the town limits of Lyman, it enters a small commercial district.