South Carolina Highway 389 (SC 389) is a 13.730-mile-long (22.096 km) state highway in the U.S. state of South Carolina.

It travels to the southeast, enters Orangeburg County, and intersects SC 394 (Salley Road) at a point northeast of Salley.

Less than one mile (1.6 km) later, it intersects SC 3 (Capital Way).

The highway continues to the southeast and enters the city limits of Neeses.

It curves to the east-northeast and crosses over railroad tracks before meeting its eastern terminus, an intersection with U.S. Route 321 (US 321; Savannah Highway).