South Carolina Highway 63 (SC 63) is a 28.200-mile-long (45.384 km) state highway in the U.S. state of South Carolina.

The highway is designated on a north–south direction, though it is signed as and located physically on an east–west orientation, from U.S. Route 278 (US 278) in Varnville to SC 64 Business (SC 64 Bus.)

[3] South Carolina Highway 63 Alternate (SC 63 Alt.)

was an alternate route that existed east-southeast of Islandton.

It was established in February 1938 as a partial renumbering of SC 63.