SC 764 begins at an intersection with U.S. Route 76 (US 76) and US 378 (Garners Ferry Road), northeast of McEntire Joint National Guard Base, and east-southeast of Horrell Hill, within Richland County.

The highway curves back to the southeast and begins paralleling railroad tracks; then, it enters Eastover.

In town, it passes a U.S. Post Office before intersecting the southern terminus of SC 263 (Vanboklen Street).

SC 764 continues traveling through rural areas of the county and curves to the east-northeast, where it no longer parallels the railroad tracks mentioned above.

A very short distance later, it meets its eastern terminus, an intersection with US 601 (McCords Ferry Road).