South Carolina Highway 263 (SC 263) is a 5.250-mile (8.449 km) state highway in the U.S. state of South Carolina.

The highway connects Eastover with rural areas of Richland County.

It travels to the northeast and leaves the city limits.

Approximately 2,500 feet (760 m) later, it intersects U.S. Route 601 (US 601; McCords Ferry Road).

Farther to the northeast, it meets its northern terminus, an intersection with US 76/US 378 (Garners Ferry Road).