South Carolina Highway 80 (SC 80) is a 5.620-mile (9.045 km) primary state highway in the state of South Carolina.

The highway serves as a bypass, connecting SC 14 to U.S. Route 29 (US 29) in Greer.

Going in a northeasterly direction, the first 0.8 miles (1.3 km) include a narrow median before splitting into a divided highway.

The highway ends at US 29 (Wade Hampton Boulevard).

It was decommissioned after Lake Hartwell formed a gap in the highway with the westernmost part becoming part of SC 243 and the rest becoming Old Dobbins Bridge Road (S-4-22 and S-4-23).