SC 14 connects Laurens and Landrum with Greer, the city between Greenville and Spartanburg where the highway crosses I-85 and US 29.

The highway also parallels I-385 through Fountain Inn and Simpsonville, South Carolina in southeastern Greenville County.

The state highway runs concurrently with the four-lane freeway to a modified diamond interchange at the southern edge of Fountain Inn.

The highway crosses Gilder Creek and passes through the unincorporated Greenville suburb of Five Forks, where the highway gains a center turn lane, meets the western end of SC 296 (Five Forks Road), and intersects SC 146 (Woodruff Road).

Just north of I-85, SC 14 returns to Greenville County and becomes a six-lane highway with a center turn lane that passes along the western edge of the airport property.

[5][6] SC 14 enters the downtown area of Greer and drops to two lanes after crossing over Norfolk Southern Railway's Greenville District and meeting CSX's Spartanburg Subdivision at grade.

On the northern edge of Greer, the highway crosses Frohawk Creek and the South Tyger River just downstream from the dam that impounds Cunningham Lake.

SC 14's name becomes Rutherford Street as it passes through the town of Landrum, where it intersects US 176 (Howard Avenue) and Norfolk Southern's W Line.

On the eastern edge of town, the state highway reaches its northern terminus at a diamond interchange with I-26.

The highway begins to curve to the north-northwest and passes Prisma Health Greer Memorial Hospital.