South Carolina Highway 88 (SC 88) is a 14.350-mile (23.094 km) state highway in northern Anderson County, South Carolina with a brief entry into southern Pickens County, connecting Pendleton and areas south of Powdersville.

; North Mechanic Street) in downtown Pendleton.

However, SCDOT designates the western terminus to not start until North Broad Street a few blocks later.

East of Pendleton, SC 88 travels through somewhat rural areas and has a roundabout intersection with US 178.

The route continues until it terminates at an intersection with SC 8, west of the suburban areas of Powdersville.