South Lenoir High School is located in Deep Run, North Carolina, USA.

It is part of the Lenoir County Public School system.

In 1964, the county's schools consolidated and Deep Run closed and was reopened at South Lenoir for high school students in Lenoir County south of the Neuse River.

The new school's nickname was the "Rebels" before changing to the "Blue Devils" after the integration of white and black students in 1970.

In November 2014, California sibling band Echosmith performed at South Lenoir, and sang songs such as "Cool Kids.