South Main Street District is a historic district in Middletown, Ohio.

It contains 76 contributing buildings, including single-dwelling, professional, and specialty store uses.

The district was listed in the National Register of Historic Places in 1974.

[1] It includes the John B. Tytus House, which is a National Historic Landmark.

This article about a property in Butler County, Ohio on the National Register of Historic Places is a stub.