It became an important station on the Overland Stage Route for the delivery of passengers and mail between Atchison, Kansas and Salt Lake City.
[8] In 1859, a branch of the trail away from the South Platte River was established in the wilderness near the present day city of Fort Morgan during the gold rush to reduce the length of the trip to Denver.
[6] A number of Cheyenne north of Denver on the South Platte Trail were killed by soldiers of the First Colorado Cavalry in the spring of 1864.
[3] Julesburg was attacked on January 7, 1865 by about 1,000 Cheyenne and Sioux men in retribution for the Sand Creek massacre (November 29, 1864).
[10] After that, three groups of Native Americans, the Arapaho, Cheyenne, and Sioux, engaged in an attack on stage stations and ranches along the South Platte Trail over a period of six days.