[1] The museum was specifically established in 1998 to house "Ötzi", a well-preserved natural mummy of a man from about 3300 BC (53 centuries ago).

The world's oldest complete copper age axe was found among his extensive equipment, which also comprised a rather complex fire-lighting kit and a quiver loaded with 12 arrows, only two of which were finished, clothing, and a flint knife complete with its sheath.

The body is held in a climate-controlled chamber within the museum at a temperature of -6 °Celsius and 98% humidity, replicating glacier conditions in which it was found.

Along with original finds, models, reconstructions, and multimedia presentations show Ötzi in the context of the early history of the southern Alpine region.

Converted from the former branch building of the Austro-Hungarian Bank,[3] the museum covers the history and archaeology of the southern Alpine region from the Palaeolithic and Mesolithic (15,000 BC) up to 800 AD.