U.S. Route 6, the Mid-Cape Highway, is to the north, beyond which is the CDP of Yarmouth Port.

[3] As of the census[6] of 2000, there were 11,603 people, 5,485 households, and 3,181 families residing in the CDP.

36.3% of all households were made up of individuals, and 22.3% had someone living alone who was 65 years of age or older.

Civil engineer and philanthropist Charles Henry Davis lived and worked in South Yarmouth.

[7][8] Former NHRA drag racing Pro Stock star Scott Geoffrion was born in South Yarmouth.