The Southern Rocky Mountain Front had a population of 5,467,633 according to the 2010 United States census.

The Colorado Eastern Plains, Nebraska Panhandle and Albany County, Wyoming, among other areas, are culturally and economically tied to the region, though they are not considered a part of it.

The region was established, along with ten other megaregions throughout the United States, by America 2050 in response to President Barack Obama’s efforts to improve the country’s infrastructure.

[6] Interstate 25 runs through the Southern Rocky Mountain Front north from Albuquerque, NM to Cheyenne, WY.

Major east and west routes running through the region are I-40 through Albuquerque, I-70 through Denver, and I-80 through Cheyenne.